Copper-Catalyzed Condensation Reaction of Amines with 1,3-Dicarbonyl Compounds to Produce Enaminones
نویسندگان
چکیده
منابع مشابه
Highly enantioselective copper-catalyzed propargylic substitution of propargylic acetates with 1,3-dicarbonyl compounds.
A chiral tridentate ketimine P,N,N-ligand has been successfully applied in the copper-catalyzed enantioselective propargylic substitution of propargylic acetates with a variety of β-dicarbonyl compounds, in which excellent enantioselectivities (up to >99% ee) and high yields have been obtained.
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A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)(2) and Cs(2)CO(3) has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give α-branched amines in good yields.
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A simple and convenient copper-catalyzed hydroamination of arylacetylenes with secondary amines has been performed giving a simple access to aliphatic amines after reduction of the hydroaminated products (E-enamines). Here we described a mild catalytic system utilizing CuCN precatalyst without any additive ligands in a solvent-free system.
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A highly efficient, tetrakis(acetonitrile)copper(I) hexafluorophosphate [Cu ACHTUNGTRENNUNG(MeCN)4PF6]catalyzed tandem Cu(I)-carbene N H insertion/ Cu(I)-catalyzed hydroamination of alkynes, which leads to sequential formation of two C N bonds to yield isoindole derivatives, has been developed.
متن کاملBoronic acid catalyzed ene carbocyclization of acetylenic dicarbonyl compounds.
The discovery and development of an efficient ene carbocyclization of 1,3-dicarbonyl compounds bearing pendent terminal alkyne substituents under 3-nitrobenzeneboronic acid catalysis is described. The reaction is efficient, easy to perform and general to a wide range of ketoester substrates.
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ژورنال
عنوان ژورنال: Chinese Journal of Organic Chemistry
سال: 2013
ISSN: 0253-2786
DOI: 10.6023/cjoc201301012